In 1466, the confraternity of Santa Maria del Paradiso, was founded around the cult of an image at the site. In 1612 the confraternity changed its name to the Confraternity of San Carlo Borromeo. The Oratory chapel was built in 1667. They engaged the painter Giacomo Friani, to fresco the ceilings. The center fresco depicts the Ecstasy of San Carlo and the Madonna. A series of medallions with the life of San Carlo were completed by Giovanni Battista Bolognini.
After the Napoleonic invasions, the oratory was closed, only to reopen in 1833. In 1896, the property was given to the Salesian order. it underwent restoration in 1906.
The oratory was one of the few buildings left intact in the neighborhood after the Allied bombings of January 29, 1944. It is now used for cultural activities.
Another similar baroque oratory in Bologna is the Oratorio di San Filippo Neri.
- Bologna Welcome, entry on oratory.