OSBPL9

Oxysterol binding protein-like 9 is a protein that in humans is encoded by the OSBPL9 gene.

OSBPL9
Identifiers
Aliases	OSBPL9, ORP-9, ORP9, oxysterol binding protein like 9
External IDs	OMIM: 606737; MGI: 1923784; HomoloGene: 69380; GeneCards: OSBPL9; OMA:OSBPL9 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1p32.3 Start 51,577,179 bp End 51,798,427 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4|4 C7 Start 109,061,145 bp End 109,202,272 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon right lung popliteal artery tibial arteries sural nerve Epithelium of choroid plexus renal medulla retinal pigment epithelium right coronary artery gastric mucosa Top expressed in stroma of bone marrow right kidney granulocyte proximal tubule carotid body iris ankle conjunctival fornix vestibular membrane of cochlear duct neural layer of retina More reference expression data BioGPS n/a
Gene ontology Molecular function lipid binding sterol transporter activity sterol binding Cellular component endosome Golgi apparatus membrane late endosome membrane cytosol intracellular membrane-bounded organelle Biological process lipid transport bile acid biosynthetic process sterol transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 114883 100273 Ensembl ENSG00000117859 ENSMUSG00000028559 UniProt Q96SU4 A2A8Z1 RefSeq (mRNA) NM_024586 NM_148904 NM_148905 NM_148906 NM_148907 NM_148908 NM_148909 NM_001330580 NM_001350208 NM_001350209 NM_001350210 NM_001134791 NM_133885 NM_173350 NM_001346502 NM_001355190 NM_001355191 NM_001368727 RefSeq (protein) NP_001317509 NP_078862 NP_683702 NP_683703 NP_683704 NP_683705 NP_683706 NP_683707 NP_001337137 NP_001337138 NP_001337139 NP_001128263 NP_001333431 NP_598646 NP_775485 NP_001342119 NP_001342120 NP_001355656 Location (UCSC) Chr 1: 51.58 – 51.8 Mb Chr 4: 109.06 – 109.2 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although some members contain only the sterol-binding domain. This family member functions as a cholesterol transfer protein that regulates Golgi structure and function. Multiple transcript variants, most of which encode distinct isoforms, have been identified. Related pseudogenes have been identified on chromosomes 3, 11 and 12.

Further reading

• Ngo M, Ridgway ND (Mar 2009). "Oxysterol binding protein-related Protein 9 (ORP9) is a cholesterol transfer protein that regulates Golgi structure and function". Molecular Biology of the Cell. 20 (5): 1388–99. doi:10.1091/mbc.E08-09-0905. PMC 2649274. PMID 19129476.
• Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S (Jun 2009). "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach". Analytical Chemistry. 81 (11): 4493–501. doi:10.1021/ac9004309. PMID 19413330.
• Perttilä J, Merikanto K, Naukkarinen J, Surakka I, Martin NW, Tanhuanpää K, Grimard V, Taskinen MR, Thiele C, Salomaa V, Jula A, Perola M, Virtanen I, Peltonen L, Olkkonen VM (Aug 2009). "OSBPL10, a novel candidate gene for high triglyceride trait in dyslipidemic Finnish subjects, regulates cellular lipid metabolism". Journal of Molecular Medicine. 87 (8): 825–35. doi:10.1007/s00109-009-0490-z. PMC 2707950. PMID 19554302.
• Chen T, Huang Z, Wang L, Wang Y, Wu F, Meng S, Wang C (Jul 2009). "MicroRNA-125a-5p partly regulates the inflammatory response, lipid uptake, and ORP9 expression in oxLDL-stimulated monocyte/macrophages". Cardiovascular Research. 83 (1): 131–9. doi:10.1093/cvr/cvp121. PMID 19377067.
• Wyles JP, Ridgway ND (Jul 2004). "VAMP-associated protein-A regulates partitioning of oxysterol-binding protein-related protein-9 between the endoplasmic reticulum and Golgi apparatus". Experimental Cell Research. 297 (2): 533–47. doi:10.1016/j.yexcr.2004.03.052. PMID 15212954.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (Jan 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Sowa ME, Bennett EJ, Gygi SP, Harper JW (Jul 2009). "Defining the human deubiquitinating enzyme interaction landscape". Cell. 138 (2): 389–403. doi:10.1016/j.cell.2009.04.042. PMC 2716422. PMID 19615732.
• Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD (Nov 2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". American Journal of Human Genetics. 85 (5): 628–42. doi:10.1016/j.ajhg.2009.10.014. PMC 2775832. PMID 19913121.
• Lessmann E, Ngo M, Leitges M, Minguet S, Ridgway ND, Huber M (Feb 2007). "Oxysterol-binding protein-related protein (ORP) 9 is a PDK-2 substrate and regulates Akt phosphorylation". Cellular Signalling. 19 (2): 384–92. doi:10.1016/j.cellsig.2006.07.009. PMID 16962287.
• Jaworski CJ, Moreira E, Li A, Lee R, Rodriguez IR (Dec 2001). "A family of 12 human genes containing oxysterol-binding domains". Genomics. 78 (3): 185–96. doi:10.1006/geno.2001.6663. PMID 11735225.
• Lehto M, Laitinen S, Chinetti G, Johansson M, Ehnholm C, Staels B, Ikonen E, Olkkonen VM (Aug 2001). "The OSBP-related protein family in humans". Journal of Lipid Research. 42 (8): 1203–13. doi:10.1016/S0022-2275(20)31570-4. PMID 11483621.
• Zhou Y, Li S, Mäyränpää MI, Zhong W, Bäck N, Yan D, Olkkonen VM (Nov 2010). "OSBP-related protein 11 (ORP11) dimerizes with ORP9 and localizes at the Golgi-late endosome interface". Experimental Cell Research. 316 (19): 3304–16. doi:10.1016/j.yexcr.2010.06.008. PMID 20599956.
• Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S (Oct 2010). "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study". Diabetes Care. 33 (10): 2250–3. doi:10.2337/dc10-0452. PMC 2945168. PMID 20628086.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.