OR2A4

Olfactory receptor 2A4 is a protein that in humans is encoded by the OR2A4 gene.

OR2A4
Identifiers
Aliases	OR2A4, OR2A10, olfactory receptor family 2 subfamily A member 4, OR2A7
External IDs	MGI: 104812; HomoloGene: 27232; GeneCards: OR2A4; OMA:OR2A4 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6q23.2 Start 131,699,644 bp End 131,701,401 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6|6 B2.1 Start 43,149,074 bp End 43,154,394 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in epithelium of colon mucosa of transverse colon bone marrow cells ventricular zone right coronary artery endometrium ganglionic eminence placenta liver muscle tissue Top expressed in testicle spermatid More reference expression data BioGPS n/a
Gene ontology Molecular function G protein-coupled receptor activity olfactory receptor activity transmembrane signaling receptor activity signal transducer activity molecular function Cellular component integral component of membrane recycling endosome mitotic spindle midzone mitotic spindle pole plasma membrane cleavage furrow membrane Flemming body Biological process positive regulation of cytokinesis sensory perception of smell detection of chemical stimulus involved in sensory perception of smell regulation of actin cytoskeleton organization detection of chemical stimulus involved in sensory perception signal transduction response to stimulus G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 79541 18310 Ensembl ENSG00000180658 ENSMUSG00000043605 UniProt O95047 P34984 RefSeq (mRNA) NM_030908 NM_146652 RefSeq (protein) NP_112170 NP_666863 Location (UCSC) Chr 6: 131.7 – 131.7 Mb Chr 6: 43.15 – 43.15 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.

See also

• Olfactory receptor

Further reading

• Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

External links

• OR2A4+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.