OLA1

Obg-like ATPase 1 is an enzyme that in humans is encoded by the OLA1 gene. Ola1 belongs to the protein family of Obg-like GTPases but defines an exceptional example of a protein that has evolved altered nucleotide specificity and binds adenosine triphosphate (ATP) with higher affinity than guanosine triphosphate (GTP).

OLA1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2OHF
Identifiers
Aliases	OLA1, DOC45, GBP45, GTBP9, GTPBP9, PTD004, Obg-like ATPase 1, Obg like ATPase 1
External IDs	OMIM: 611175; MGI: 1914309; HomoloGene: 5361; GeneCards: OLA1; OMA:OLA1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2q31.1 Start 174,072,447 bp End 174,248,599 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 C3 Start 72,923,145 bp End 73,049,268 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell ganglionic eminence lateral nuclear group of thalamus pons Brodmann area 23 gingival epithelium lactiferous duct parotid gland entorhinal cortex ventricular zone Top expressed in Paneth cell tail of embryo cumulus cell condyle ureter medial ganglionic eminence primitive streak epiblast barrel cortex hair follicle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding GTP binding protein binding hydrolase activity metal ion binding ATP binding ATPase activity cadherin binding ribosome binding ribosomal large subunit binding Cellular component centrosome nucleolus extracellular exosome membrane nucleus extracellular region cytoplasm cytosol platelet alpha granule lumen Biological process ATP metabolic process platelet degranulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 29789 67059 Ensembl ENSG00000138430 ENSMUSG00000027108 UniProt Q9NTK5 Q9CZ30 RefSeq (mRNA) NM_013341 NM_001011708 NM_001328688 NM_025942 NM_030091 RefSeq (protein) NP_001011708 NP_001315617 NP_037473 NP_080218 NP_084367 Location (UCSC) Chr 2: 174.07 – 174.25 Mb Chr 2: 72.92 – 73.05 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
• Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

External links

• Overview of all the structural information available in the PDB for UniProt: Q9NTK5 (Obg-like ATPase 1) at the PDBe-KB.