O16 or O-16 may refer to:
- Curtiss O-16 Falcon, an observation aircraft of the United States Army Air Corps
- Garberville Airport, in Humboldt County, California, United States
- HNLMS O 16, a submarine of the Royal Netherlands Navy
- Oxygen-16, an isotope of oxygen
- USS O-16 (SS-77), a submarine of the United States Navy
This disambiguation page lists articles associated with the same title formed as a letter–number combination.
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