O'Bryant may refer to:

  • Hugh O'Bryant (1813–1883), the first mayor of Portland, Oregon, United States, serving from 1851–1852
  • Jimmy O'Bryant (1896–1928), American jazz clarinetist, often compared to Johnny Dodds
  • John D. O'Bryant (1931–1992), the first African American to be elected to Boston's School Committee in 1977
  • Johnny O'Bryant III (born 1993), American professional basketball player for Crvena Zvezda of the Adriatic League and the EuroLeague
  • Patrick O'Bryant (born 1986), US-born Central African professional basketball player for the London Lightning of the National Basketball League of Canada

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