Guanine nucleotide-binding protein-like 3, also known as nucleostemin, is a protein that in humans is encoded by the GNL3 gene.[4][5][6] It is found within the nucleolus that binds p53.[7] Nucleostemin regulates the cell cycle and affects cell differentiation, decreasing in amount as this differentiation progresses.[7] It is a marker for many stem cells and cancer cells.[8]

GNL3
Identifiers
AliasesGNL3, C77032, E2IG3, NNP47, NS, G protein nucleolar 3
External IDsOMIM: 608011; MGI: 1353651; HomoloGene: 56670; GeneCards: GNL3; OMA:GNL3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_206826
NM_014366
NM_206825

NM_153547
NM_178846

RefSeq (protein)

NP_055181
NP_996561
NP_996562

NP_705775

Location (UCSC)n/aChr 14: 30.73 – 30.74 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

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GNL3 has been shown to interact with Mdm2[9] and P53.[5]

References

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  1. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000042354Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ Charpentier AH, Bednarek AK, Daniel RL, Hawkins KA, Laflin KJ, Gaddis S, MacLeod MC, Aldaz CM (Nov 2000). "Effects of estrogen on global gene expression: identification of novel targets of estrogen action". Cancer Res. 60 (21): 5977–5983. PMID 11085516.
  5. ^ a b Tsai RY, McKay RD (Dec 2002). "A nucleolar mechanism controlling cell proliferation in stem cells and cancer cells". Genes Dev. 16 (23): 2991–3003. doi:10.1101/gad.55671. PMC 187487. PMID 12464630.
  6. ^ "Entrez Gene: GNL3 guanine nucleotide binding protein-like 3 (nucleolar)".
  7. ^ a b Ross MH, Pawlina W (2011). Histology : a text and atlas : with correlated cell and molecular biolog. Philadelphia: Wolters Kluwer/Lippincott Williams Wilkins Health. p. 79. ISBN 978-0-7817-7200-6.
  8. ^ Niall M. Adams (29 November 2010). Advances in Nuclear Architecture. Springer. p. 31. ISBN 978-90-481-9898-6. Retrieved 27 September 2011.
  9. ^ Dai MS, Sun XX, Lu H (Jul 2008). "Aberrant expression of nucleostemin activates p53 and induces cell cycle arrest via inhibition of MDM2". Mol. Cell. Biol. 28 (13): 4365–4376. doi:10.1128/MCB.01662-07. PMC 2447154. PMID 18426907.

Further reading

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