In molecular biology, the Nrf2 internal ribosome entry site (IRES) is an RNA element present in the 5′ UTR of the mRNA encoding the transcription factor Nrf2. It contains a stem-loop structure upstream of a ribosome binding site. This stem loop inhibits ribosome binding and translation of Nrf2 under normal conditions, but allows translation under oxidative stress conditions.[1][2][3]
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References edit
- ^ Li, W; Thakor, N; Xu, EY; Huang, Y; Chen, C; Yu, R; Holcik, M; Kong, AN (January 2010). "An internal ribosomal entry site mediates redox-sensitive translation of Nrf2". Nucleic Acids Research. 38 (3): 778–788. doi:10.1093/nar/gkp1048. PMC 2817467. PMID 19934254.
- ^ Zhang, J; Dinh, TN; Kappeler, K; Tsaprailis, G; Chen, QM (June 2012). "La autoantigen mediates oxidant induced de novo Nrf2 protein translation". Molecular & Cellular Proteomics. 11 (6): M111.015032. doi:10.1074/mcp.m111.015032. PMC 3433904. PMID 22207702.
- ^ Shay, KP; Michels, AJ; Li, W; Kong, AN; Hagen, TM (June 2012). "Cap-independent Nrf2 translation is part of a lipoic acid-stimulated detoxification stress response". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1823 (6): 1102–1109. doi:10.1016/j.bbamcr.2012.04.002. PMC 4012555. PMID 22521877.