The Nickel/Cobalt Transporter (NicO) Family is a member of the Lysine Exporter (LysE) Superfamily.[1]

Homology

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Homologues of the NicO family have differing predicted topologies: 6, 7 and 8 TMSs. One such homologue, RcnA (YohM; TC# 2.A.113.1.1) of E. coli (274 aas) has 6 putative transmembrane segments (TMSs) in a 3 + 3 arrangement with a large hydrophilic loop between putativeTMSs 3 and 4.[2] Several homologues of RcnA (e.g., RcnA homologue from Ralstonia solanacearum; TC# 2.A.113.1.3; CAD17703) have 7 putative TMSs (4 + 3). Still another homologue, UreH of Methanocaldococcus janaschii (TC# 2.A.113.1.4) has 6 putative TMSs in a more characteristic 3 + 3 TMS arrangement. The NicO family within the LysE superfamily may have a common origin with the TOG superfamily, having lost TMSs 1 and 4 in the 8 TMS TOG superfamily topology.[3]

Function

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This protein is believed to catalyze Co2+ and Ni2+ efflux.[2]

The overall reaction catalyzed by proteins of the NicO family is probably:

[Ni2+ or Co2+] (in) → [Ni2+ or Co2+] (out).

See also

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Further reading

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References

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  1. ^ Tsu, Brian V.; Saier, Milton H. (2015-01-01). "The LysE Superfamily of Transport Proteins Involved in Cell Physiology and Pathogenesis". PLOS ONE. 10 (10): e0137184. Bibcode:2015PLoSO..1037184T. doi:10.1371/journal.pone.0137184. ISSN 1932-6203. PMC 4608589. PMID 26474485.
  2. ^ a b Rodrigue, Agnès; Effantin, Géraldine; Mandrand-Berthelot, Marie-Andrée (2005-04-15). "Identification of rcnA (yohM), a Nickel and Cobalt Resistance Gene in Escherichia coli". Journal of Bacteriology. 187 (8): 2912–2916. doi:10.1128/JB.187.8.2912-2916.2005. ISSN 0021-9193. PMC 1070376. PMID 15805538.
  3. ^ "The Nickel/cobalt Transporter (NicO) Family". Transporter Classification Database. Retrieved 2016-02-29.
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