Hendel was born in the United States and attended high school at the Yeshivah of Flatbush. After graduating in 1969, he attended New York University and graduated in 1973 with a BA in sociology and Jewish studies. He studied Talmud at Yeshiva University with Rabbi Joseph B. Soloveitchik. He then studied law at Hofstra University, and completed his law degree in 1976. He was then admitted to the New York State Bar Association. He worked in the Legal Aid Office and in private practice.
In 1983, Hendel made aliyah to Israel, and settled in Beersheba. From 1983 to 1988, he worked in the southern district prosecutor's office. In 1988, he became a judge on the Beersheba Magistrate's Court, a position he held until 1997. In 1997, he became a judge on the Beersheba District Court, eventually becoming its Vice-President. In 2009, he was appointed to serve on the Supreme Court by the Judicial Selection Committee.
His wife, Marcie, is a psychologist. The couple has five sons.
- "Neal Hendel". Israeli Judicial Authority. Retrieved 24 August 2009.
- Gil Ronen (24 August 2009). "Yeshiva of Flatbush High School graduate appointed to Israel's Supreme Court". Israel National News. Retrieved 24 August 2009.