His father was Aenghus, who was 3rd in descent from Lughaidh, King of Munster. He died in 564. He was a spiritual student of Columba and founded monasteries throughout Ulster, serving as an abbot at St Naul's Abbey, Inver (County Donegal), Kinawley (Cill Naile), Inver Naile (at Raphoe, County Donegal), and Devenish Island, where he succeeded Saint Molaise.
A well in his memory still exists beside Kinawley Church, where the handle of his bell was preserved up to the 19th century. A Life of Naile dating from c.1520 is found in 'Miscellanea hagiographica Hibernica: vitae adhuc ineditae sanctorum Mac Creiche, Naile, Cranat'.
Natalis' feast day is 27 January.
- "St Natalis". Catholic Online. Retrieved 8 July 2016.
- "Plummer, C., "Betha Naile: Life of Naile", in Miscellanea hagiographica Hibernica (1925) • CODECS: Online Database and e-Resources for Celtic Studies".
- Entry at Patron Saints Index
- Life of Naile. pp. 134–135, 146–148. Archived from the original on 26 October 2010. Retrieved 31 March 2010.