Wikipedia

Nagy Habib

Nagy Habib (born 1952), is professor of hepato-biliary surgery at Imperial College, London, and is known for devising radio-frequency based liver resection devices which remove liver tumour with minimal blood loss. His work has also focused on stem cells and gene therapy.

Nagy Habib
Nagy Habib (2021)
Born1952
NationalityBritish, Egyptian
OccupationSurgeon
Known forRadio-frequency based surgical devices
Medical career
ProfessionLiver surgeon
InstitutionsImperial College, London
Research

Early life and education edit

Nagy Habib was born in Cairo, Egypt, 1952.[1] He trained under both Henri Bismuth [fr] and the transplant surgeon Thomas Starzl.[2]

Career edit

His work has focused on stem cells and gene therapy.[3] He led the first clinical trial in the use of oncolytic adenoviruses for the treatment of liver cancer.[4] It was carried out by means of a locally restricted injection into the main blood vessel to the liver.[5][6] The findings were published in 2001.[5][6] It was found to be safe, but the second phase of the trial did not find it effective.[5][6] In 2004, he took stem cells from a person with liver cirrhosis and injected them into their liver artery, resulting in some improvement of liver function.[7]

In 2003 he was appointed professor of hepato-biliary surgery at Imperial College, London.[8] In June 2007 he was appointed pro-rector for Commercial Affairs at Imperial.[4]

Habib developed several radio-frequency (RF) based liver resection devices.[9][10] He devised the Habib RF device using the Habib needle, which has a modified version called the Habib 4X.[10] It removes tumour with minimal blood loss.[10] The procedure has come to be known as 'Habib's resection'.[11]

MiNA Therapeutics, a biotechnology company dealing in small activating RNA technology was co-founded by Habib and his son Robert.[12]

Awards and honours edit

He was awarded the Takreem award in December 2012, for his work in liver cancer and radio-frequency based liver resection.[4]

Selected publications edit

Articles edit

  • Habib, Nagy A.; Sarraf, Catherine E.; Mitry, Ragai R.; Havlík, Roman; Nicholls, Joanna; Kelly, Michael; Vernon, Clare C.; Gueret-Wardle, David; El-Masry, Rashad; Salama, Hosny; Ahmed, Rasha; Michail, Nagy; Edward, Ezzat; Jensen, Steen L. (10 February 2001). "E1B-deleted adenovirus (dl1520) gene therapy for patients with primary and secondary liver tumors". Human Gene Therapy. 12 (3): 219–226. doi:10.1089/10430340150218369. ISSN 1043-0342. PMID 11177559. (Co-author)
  • Habib, Nagy; Salama, Hosny; Abd El Latif Abu Median, Ahmed; Isac Anis, Ilia; Abd Al Aziz, Rasha Ahmed; Sarraf, Catherine; Mitry, Ragai; Havlik, Roman; Seth, Prem; Hartwigsen, Jack; Bhushan, Reva; Nicholls, Joanna; Jensen, Steen (March 2002). "Clinical trial of E1B-deleted adenovirus (dl1520) gene therapy for hepatocellular carcinoma". Cancer Gene Therapy. 9 (3): 254–259. doi:10.1038/sj.cgt.7700431. ISSN 1476-5500. PMID 11896441. S2CID 42290755. (Co-author)
  • Havlik, Roman; Jiao, Long R.; Nicholls, Joanna; Jensen, Steen Lindkaer; Habib, Nagy A. (April 2002). "Gene therapy for liver metastases". Seminars in Oncology. 29 (2): 202–208. doi:10.1053/sonc.2002.31678. ISSN 0093-7754. PMID 11951219. (Co-author)
  • Ferko, A.; Leško, M.; Šubrt, Z.; Melichar, B.; Hoffman, P.; Dvořák, P.; Vacek, Z.; Liao, L.R.; Habib, N.A.; Kočí, J.; Motyčka, P. (December 2006). "A modified radiofrequency-assisted approach to right hemihepatectomy". European Journal of Surgical Oncology (EJSO). 32 (10): 1209–1211. doi:10.1016/j.ejso.2006.07.013. PMID 16950592. (Co-author)

Books edit

References edit

  1. ^ "Habib Nagy / Curriculum Vitae". www.s466593873.onlinehome.fr. Retrieved 28 November 2021.
  2. ^ "Interview with Nagy Habib". Oligonucleutide Therapeutic Society. 8 January 2019. Archived from the original on 29 November 2021. Retrieved 27 November 2021.
  3. ^ Sugand, Kapil; Hills, Alexander (22 March 2008). "Professor Nagy Habib". British Medical Journal. 336 (7645): s109. doi:10.1136/bmj.39510.543056.CE. ISSN 0959-8138. S2CID 80337462.
  4. ^ a b c "Home - Professor Nagy Habib". www.imperial.ac.uk. Archived from the original on 27 November 2021. Retrieved 27 November 2021.
  5. ^ a b c Doerfler, Walter; Böhm, Petra (2013). Adenoviruses: Model and Vectors in Virus-Host Interactions: Immune System, Oncogenesis, Gene Therapy. Springer. pp. 316–320. ISBN 978-3-662-05599-1.
  6. ^ a b c Avila, M. A.; Berasain, C.; Sangro, B.; Prieto, J. (June 2006). "New therapies for hepatocellular carcinoma". Oncogene. 25 (27): 3866–3884. doi:10.1038/sj.onc.1209550. hdl:10171/27496. ISSN 1476-5594. PMID 6799628. S2CID 8901643.
  7. ^ Nill, Kimball (2005). Glossary of Biotechnology Terms, Fourth Edition (4th ed.). Boca Raton: CRC Press. p. 9. ISBN 0-8493-6609-7.
  8. ^ "Professor Nagy Habib". www.imperial.nhs.uk. Archived from the original on 29 November 2021. Retrieved 28 November 2021.
  9. ^ Krestanova, Alice; Kracmar, Jan; Hlavackova, Milada; Kubicek, Jan; Vavra, Petr; Penhaker, Marek; Ihnat, Petr (2019). "Design and testing of radio frequency instrument RONLINE". In Pietka, Ewa; Badura, Pawel; Kawa, Jacek; Wieclawek, Wojciech (eds.). Information Technology in Biomedicine. Springer. p. 638. ISBN 978-3-030-23761-5.
  10. ^ a b c Kumaran, Vinay (2016). "2. Techniques for transection of the liver". Techniques of Liver Surgery. New Delhi: JP Medical Ltd. p. 15. ISBN 978-93-85891-56-4.
  11. ^ Penhaker, Marek; Vavra, Petr; Hlavackova, Mlada; Kracmar, Jan; Sikora, Tadeusz; Prokop, Lucas (2012). "Linear surgical instrument for bipolar multi electrode radiofrquency ablation". In Madarász, Ladislav; Živčák, Jozef (eds.). Aspects of Computational Intelligence: Theory and Applications: Revised and Selected Papers of the 15th IEEE International Conference on Intelligent Engineering Systems 2011, INES 2011. Springer. p. 308. ISBN 978-3-642-30668-6.
  12. ^ Ralph, Alex (12 May 2021). "Father and son pioneers at MiNA Therapeutics clinch US pharma deal". The Times. Archived from the original on 8 December 2021. Retrieved 8 December 2021.
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