NXF2

NXF2
Identifiers
Aliases	NXF2, CT39, TAPL-2, TCP11X2, nuclear RNA export factor 2
External IDs	OMIM: 300315; MGI: 1933192; HomoloGene: 88604; GeneCards: NXF2; OMA:NXF2 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	102,326,722 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	133,865,503 bp
RNA expression pattern
	Top expressed in
	testicle; ; gonad; ; right testis; ; left testis; ; right uterine tube; ; pituitary gland; ; anterior pituitary; ; olfactory zone of nasal mucosa; ; hypothalamus; ; islet of Langerhans;
	Top expressed in
	spermatid; ; Gonadal ridge; ; embryo; ; embryo; ; testicle; ; spermatocyte; ; seminiferous tubule; ; embryo; ; ganglion of neuraxis; ; genital tubercle;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleic acid binding; RNA binding;
Cellular component	cytoplasm; nuclear RNA export factor complex; nucleus; nucleoplasm; cytosol;
Biological process	multicellular organism development; poly(A)+ mRNA export from nucleus; mRNA transport; RNA transport; mRNA export from nucleus;
	Sources:Amigo / QuickGO
Orthologs
	56001
	83454
	ENSG00000269405
	ENSMUSG00000009941
	Q9GZY0
	n/a
	NM_022053; NM_001039910; NM_017809
	NM_001289735; NM_001289736; NM_031259
	NP_071336; NP_001093156
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Nuclear RNA export factor 2 is a protein that in humans is encoded by the NXF2 gene.^[5]^[6]^[7]

Function

This gene is one of a family of nuclear RNA export factor genes. It encodes a protein that is involved in mRNA export, is located in the nucleoplasm, and is associated with the nuclear envelope. Alternative splicing seems to be a common mechanism in this gene family. Two variants have been found for this gene.^[7]

Interactions

NXF2 has been shown to interact with NUP214.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000269405 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000009941 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Herold A, Suyama M, Rodrigues JP, Braun IC, Kutay U, Carmo-Fonseca M, Bork P, Izaurralde E (Dec 2000). "TAP (NXF1) belongs to a multigene family of putative RNA export factors with a conserved modular architecture". Molecular and Cellular Biology. 20 (23): 8996–9008. doi:10.1128/MCB.20.23.8996-9008.2000. PMC 86553. PMID 11073998.
^ Wang PJ, McCarrey JR, Yang F, Page DC (Apr 2001). "An abundance of X-linked genes expressed in spermatogonia". Nature Genetics. 27 (4): 422–426. doi:10.1038/86927. PMID 11279525. S2CID 14200121.
^ ^a ^b "Entrez Gene: NXF2 nuclear RNA export factor 2".

Black BE, Lévesque L, Holaska JM, Wood TC, Paschal BM (Dec 1999). "Identification of an NTF2-related factor that binds Ran-GTP and regulates nuclear protein export". Molecular and Cellular Biology. 19 (12): 8616–24. doi:10.1128/MCB.19.12.8616. PMC 84993. PMID 10567585.
Jun L, Frints S, Duhamel H, Herold A, Abad-Rodrigues J, Dotti C, Izaurralde E, Marynen P, Froyen G (Sep 2001). "NXF5, a novel member of the nuclear RNA export factor family, is lost in a male patient with a syndromic form of mental retardation". Current Biology. 11 (18): 1381–1391. Bibcode:2001CBio...11.1381J. doi:10.1016/S0960-9822(01)00419-5. PMID 11566096.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000269405 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000009941 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11073998-5] Herold A, Suyama M, Rodrigues JP, Braun IC, Kutay U, Carmo-Fonseca M, Bork P, Izaurralde E (Dec 2000). "TAP (NXF1) belongs to a multigene family of putative RNA export factors with a conserved modular architecture". Molecular and Cellular Biology. 20 (23): 8996–9008. doi:10.1128/MCB.20.23.8996-9008.2000. PMC 86553. PMID 11073998.

[pmid11279525-6] Wang PJ, McCarrey JR, Yang F, Page DC (Apr 2001). "An abundance of X-linked genes expressed in spermatogonia". Nature Genetics. 27 (4): 422–426. doi:10.1038/86927. PMID 11279525. S2CID 14200121.

[entrez-7] "Entrez Gene: NXF2 nuclear RNA export factor 2".

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NXF2

Contents

Function

Interactions

References

Further reading