Neuropeptide Y receptor Y2

Neuropeptide Y receptor type 2 (Y2R) is a member of the neuropeptide Y receptor family of G-protein coupled receptors, that in humans is encoded by the NPY2R gene.

NPY2R
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2IK3
Identifiers
Aliases	NPY2R, NPY2-R, Neuropeptide Y receptor Y2
External IDs	OMIM: 162642; MGI: 108418; HomoloGene: 701; GeneCards: NPY2R; OMA:NPY2R - orthologs
Gene location (Human) Chr. Chromosome 4 (human) Band 4q32.1 Start 155,208,636 bp End 155,217,078 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3 E3|3 36.49 cM Start 82,445,690 bp End 82,455,391 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle optic nerve pancreatic ductal cell lactiferous duct prefrontal cortex hypothalamus tibialis anterior muscle nucleus accumbens right coronary artery Brodmann area 9 Top expressed in median eminence lumbar spinal ganglion arcuate nucleus dentate gyrus of hippocampal formation granule cell hippocampus proper anterior amygdaloid area subiculum CA3 field globus pallidus area postrema More reference expression data BioGPS More reference expression data
Gene ontology Molecular function neuropeptide Y receptor activity G protein-coupled receptor activity calcium channel regulator activity signal transducer activity protein binding peptide YY receptor activity signaling receptor activity Cellular component integral component of membrane membrane plasma membrane integral component of plasma membrane intracellular anatomical structure non-motile cilium cilium Biological process adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway regulation of sensory perception of pain locomotory behavior positive regulation of cytosolic calcium ion concentration positive regulation of peptide secretion outflow tract morphogenesis cardiac left ventricle morphogenesis negative regulation of nervous system process negative regulation of synaptic transmission behavioral fear response negative regulation of excitatory postsynaptic potential secretion positive regulation of circadian sleep/wake cycle, non-REM sleep positive regulation of dopamine secretion negative regulation of secretion feeding behavior negative regulation of feeding behavior nitric oxide mediated signal transduction neuropeptide signaling pathway positive regulation of smooth muscle contraction negative regulation of synaptic transmission, glutamatergic signal transduction positive regulation of cell-substrate adhesion human ageing chemical synaptic transmission G protein-coupled receptor signaling pathway negative regulation of cAMP-mediated signaling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4887 18167 Ensembl ENSG00000185149 ENSMUSG00000028004 UniProt P49146 P97295 RefSeq (mRNA) NM_000910 NM_001370180 NM_001375470 NM_001205099 NM_008731 RefSeq (protein) NP_000901 NP_001357109 NP_001362399 NP_001192028 NP_032757 Location (UCSC) Chr 4: 155.21 – 155.22 Mb Chr 3: 82.45 – 82.46 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Selective ligands

Agonists

• Neuropeptide Y (endogenous agonist, non subtype selective)
• Neuropeptide Y fragment 13-36 (NPY₂ selective agonist)
• Peptide YY
• Peptide YY 3-36 fragment

Antagonists

• BIIE-0246 (CAS# 246146-55-4)
• JNJ 5207787 (CAS# 683746-68-1)
• SF 11 (CAS# 443292-81-7)

See also

• Neuropeptide Y receptor

External links

• "Neuropeptide Y Receptors: Y₂". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2008-12-09.

Further reading

• Wan CP, Lau BH (Feb 1995). "Neuropeptide Y receptor subtypes". Life Sciences. 56 (13): 1055–64. doi:10.1016/0024-3205(95)00041-4. PMID 9001438.
• Parker E, Van Heek M, Stamford A (Apr 2002). "Neuropeptide Y receptors as targets for anti-obesity drug development: perspective and current status". European Journal of Pharmacology. 440 (2–3): 173–87. doi:10.1016/S0014-2999(02)01427-9. PMID 12007534.
• Herzog H, Hort YJ, Ball HJ, Hayes G, Shine J, Selbie LA (Jul 1992). "Cloned human neuropeptide Y receptor couples to two different second messenger systems". Proceedings of the National Academy of Sciences of the United States of America. 89 (13): 5794–8. Bibcode:1992PNAS...89.5794H. doi:10.1073/pnas.89.13.5794. PMC 402104. PMID 1321422.
• Gerald C, Walker MW, Vaysse PJ, He C, Branchek TA, Weinshank RL (Nov 1995). "Expression cloning and pharmacological characterization of a human hippocampal neuropeptide Y/peptide YY Y2 receptor subtype". The Journal of Biological Chemistry. 270 (45): 26758–61. doi:10.1074/jbc.270.45.26758. PMID 7592910.
• Lynch JW, Lemos VS, Bucher B, Stoclet JC, Takeda K (Mar 1994). "A pertussis toxin-insensitive calcium influx mediated by neuropeptide Y2 receptors in a human neuroblastoma cell line". The Journal of Biological Chemistry. 269 (11): 8226–33. doi:10.1016/S0021-9258(17)37183-1. PMID 8132547.
• Gehlert DR, Beavers LS, Johnson D, Gackenheimer SL, Schober DA, Gadski RA (Feb 1996). "Expression cloning of a human brain neuropeptide Y Y2 receptor". Molecular Pharmacology. 49 (2): 224–8. PMID 8632753.
• Yan H, Yang J, Marasco J, Yamaguchi K, Brenner S, Collins F, Karbon W (May 1996). "Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors". Proceedings of the National Academy of Sciences of the United States of America. 93 (10): 4661–5. Bibcode:1996PNAS...93.4661Y. doi:10.1073/pnas.93.10.4661. PMC 39335. PMID 8643460.
• Ammar DA, Eadie DM, Wong DJ, Ma YY, Kolakowski LF, Yang-Feng TL, Thompson DA (Dec 1996). "Characterization of the human type 2 neuropeptide Y receptor gene (NPY2R) and localization to the chromosome 4q region containing the type 1 neuropeptide Y receptor gene". Genomics. 38 (3): 392–8. doi:10.1006/geno.1996.0642. PMID 8975716.
• Snow BE, Hall RA, Krumins AM, Brothers GM, Bouchard D, Brothers CA, Chung S, Mangion J, Gilman AG, Lefkowitz RJ, Siderovski DP (Jul 1998). "GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain". The Journal of Biological Chemistry. 273 (28): 17749–55. doi:10.1074/jbc.273.28.17749. PMID 9651375.
• Caberlotto L, Fuxe K, Rimland JM, Sedvall G, Hurd YL (Sep 1998). "Regional distribution of neuropeptide Y Y2 receptor messenger RNA in the human post mortem brain". Neuroscience. 86 (1): 167–78. doi:10.1016/S0306-4522(98)00039-6. PMID 9692752. S2CID 45849983.
• Goumain M, Voisin T, Lorinet AM, Ducroc R, Tsocas A, Rozé C, Rouet-Benzineb P, Herzog H, Balasubramaniam A, Laburthe M (Jul 2001). "The peptide YY-preferring receptor mediating inhibition of small intestinal secretion is a peripheral Y(2) receptor: pharmacological evidence and molecular cloning". Molecular Pharmacology. 60 (1): 124–34. doi:10.1124/mol.60.1.124. PMID 11408607. S2CID 11573265.
• Cox HM, Tough IR (Mar 2002). "Neuropeptide Y, Y1, Y2 and Y4 receptors mediate Y agonist responses in isolated human colon mucosa". British Journal of Pharmacology. 135 (6): 1505–12. doi:10.1038/sj.bjp.0704604. PMC 1573267. PMID 11906964.
• Uddman R, Möller S, Nilsson T, Nyström S, Ekstrand J, Edvinsson L (May 2002). "Neuropeptide Y Y1 and neuropeptide Y Y2 receptors in human cardiovascular tissues". Peptides. 23 (5): 927–34. doi:10.1016/S0196-9781(02)00003-7. PMID 12084524. S2CID 31244551.
• Hyland NP, Sjöberg F, Tough IR, Herzog H, Cox HM (Jun 2003). "Functional consequences of neuropeptide Y Y 2 receptor knockout and Y2 antagonism in mouse and human colonic tissues". British Journal of Pharmacology. 139 (4): 863–71. doi:10.1038/sj.bjp.0705298. PMC 1573894. PMID 12813010.
• Hung CC, Pirie F, Luan J, Lank E, Motala A, Yeo GS, Keogh JM, Wareham NJ, O'Rahilly S, Farooqi IS (Sep 2004). "Studies of the peptide YY and neuropeptide Y2 receptor genes in relation to human obesity and obesity-related traits". Diabetes. 53 (9): 2461–6. doi:10.2337/diabetes.53.9.2461. PMID 15331560.
• Tang T, Hartig C, Chen Q, Zhao W, Kaiser A, Zhang X, Zhang H, Qu H, Yi C, Ma L, Han S, Zhao Q, Beck-Sickinger AG, Wu B (Feb 2021). "Structural basis for ligand recognition of the neuropeptide Y Y2 receptor". Nature Communications. 12 (1): 737. doi:10.1038/s41467-021-21030-9. PMC 7854658. PMID 33531491.