Neuroplastin is a protein that in humans is encoded by the NPTN gene.[5][6][7]

NPTN
Identifiers
AliasesNPTN, GP55, GP65, SDFR1, SDR1, np55, np65, neuroplastin
External IDsOMIM: 612820; MGI: 108077; HomoloGene: 7531; GeneCards: NPTN; OMA:NPTN - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001161363
NM_001161364
NM_012428
NM_017455

NM_001293673
NM_009145
NM_001357751

RefSeq (protein)

NP_001154835
NP_001154836
NP_036560
NP_059429

NP_001280602
NP_033171
NP_001344680
NP_001392991

Location (UCSC)Chr 15: 73.56 – 73.63 MbChr 9: 58.58 – 58.66 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Neuroplastin is a type I transmembrane protein belonging to the Ig superfamily. The protein is believed to be involved in cell-cell interactions or cell-substrate interactions. The alpha and beta transcripts show differential localization within the brain.[7]

In 2014, in a study led by Dr. Sylvane Desrivières, of King's College London's Institute of Psychiatry found that "teenagers who had a highly functioning NPTN gene performed better in intelligence tests"[8][9][10]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000156642Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032336Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (June 1996). "A "double adaptor" method for improved shotgun library construction". Anal Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
  6. ^ Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (June 1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
  7. ^ a b "Entrez Gene: NPTN neuroplastin".
  8. ^ Is intelligence written in the genes?
  9. ^ Researchers Find Gene that Links Grey Matter with Intelligence
  10. ^ Single nucleotide polymorphism in the neuroplastin locus associates with cortical thickness and intellectual ability in adolescents

Further reading

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