NPTN

Neuroplastin is a protein that in humans is encoded by the NPTN gene.

NPTN
Identifiers
Aliases	NPTN, GP55, GP65, SDFR1, SDR1, np55, np65, neuroplastin
External IDs	OMIM: 612820; MGI: 108077; HomoloGene: 7531; GeneCards: NPTN; OMA:NPTN - orthologs
Gene location (Human) Chr. Chromosome 15 (human) Band 15q24.1 Start 73,560,014 bp End 73,634,134 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 B Start 58,582,240 bp End 58,657,955 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 23 lateral nuclear group of thalamus cerebellar vermis germinal epithelium jejunal mucosa tail of epididymis bronchial epithelial cell visceral pleura orbitofrontal cortex caput epididymis Top expressed in nucleus accumbens superior frontal gyrus cerebellar cortex olfactory tubercle lobe of cerebellum primary visual cortex cerebellar vermis cingulate gyrus lateral geniculate nucleus prefrontal cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transmembrane transporter binding fibroblast growth factor receptor binding cell adhesion molecule binding type 1 fibroblast growth factor receptor binding cell-cell adhesion mediator activity protein binding Cellular component integral component of membrane synaptic membrane membrane postsynaptic density plasma membrane inhibitory synapse dendrite presynaptic membrane cell surface axon Schaffer collateral - CA1 synapse glutamatergic synapse GABA-ergic synapse integral component of presynaptic active zone membrane integral component of postsynaptic density membrane immunological synapse Biological process visual learning positive regulation of long-term synaptic potentiation nervous system development cell adhesion positive regulation of protein localization positive regulation of ERK1 and ERK2 cascade positive regulation of long-term neuronal synaptic plasticity positive regulation of neuron projection development positive regulation of cytosolic calcium ion concentration homophilic cell adhesion via plasma membrane adhesion molecules modulation of chemical synaptic transmission synapse organization regulation of receptor localization to synapse excitatory synapse assembly positive regulation of protein phosphorylation positive regulation of fibroblast growth factor receptor signaling pathway long-term potentiation axon guidance dendrite self-avoidance trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission negative regulation of cytokine production cellular calcium ion homeostasis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27020 20320 Ensembl ENSG00000156642 ENSMUSG00000032336 UniProt Q9Y639 P97300 RefSeq (mRNA) NM_001161363 NM_001161364 NM_012428 NM_017455 NM_001293673 NM_009145 NM_001357751 RefSeq (protein) NP_001154835 NP_001154836 NP_036560 NP_059429 NP_001280602 NP_033171 NP_001344680 NP_001392991 Location (UCSC) Chr 15: 73.56 – 73.63 Mb Chr 9: 58.58 – 58.66 Mb PubMed search
Wikidata
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Neuroplastin is a type I transmembrane protein belonging to the Ig superfamily. The protein is believed to be involved in cell-cell interactions or cell-substrate interactions. The alpha and beta transcripts show differential localization within the brain.

In 2014, in a study led by Dr. Sylvane Desrivières, of King's College London's Institute of Psychiatry found that "teenagers who had a highly functioning NPTN gene performed better in intelligence tests"

Further reading

• Langnaese K, Beesley PW, Gundelfinger ED (1997). "Synaptic membrane glycoproteins gp65 and gp55 are new members of the immunoglobulin superfamily". J. Biol. Chem. 272 (2): 821–7. doi:10.1074/jbc.272.2.821. PMID 8995369.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Saito A, Fujikura-Ouchi Y, Kuramasu A, et al. (2007). "Association study of putative promoter polymorphisms in the neuroplastin gene and schizophrenia". Neurosci. Lett. 411 (3): 168–73. doi:10.1016/j.neulet.2006.08.042. PMID 17123723. S2CID 36492996.
• Bernstein HG, Smalla KH, Bogerts B, et al. (2007). "The immunolocalization of the synaptic glycoprotein neuroplastin differs substantially between the human and the rodent brain". Brain Res. 1134 (1): 107–12. doi:10.1016/j.brainres.2006.11.090. PMID 17196182. S2CID 31095277.