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The NLPC-P60 RNA motif is a conserved RNA structure that was discovered by bioinformatics.[1] NLPC-P60 motif RNAs are found in Streptomyces.
| NLPC-P60 | |
|---|---|
 Consensus secondary structure and sequence conservation of NLPC-P60 RNA | |
| Identifiers | |
| Symbol | NLPC-P60 |
| Rfam | RF03033 |
| Other data | |
| RNA type | Cis-reg |
| SO | SO:0005836 |
| PDB structures | PDBe |
NLPC-P60 motif RNAs likely function as cis-regulatory elements, in view of their positions upstream of protein-coding genes. The RNAs are consistently located upstream of genes encoding examples of the conserved protein domain known as "NlpC/P60". The biochemical function of this domain is unknown, but it is found in lipoproteins. Additionally, genes encoding this domain are often regulated by riboswitches that sense the signaling molecule cyclic di-AMP. However, no associated between the NLPC-P60 RNA motif and cyclic di-AMP has been established.
References edit
- ^ Weinberg Z, Lünse CE, Corbino KA, Ames TD, Nelson JW, Roth A, Perkins KR, Sherlock ME, Breaker RR (October 2017). "Detection of 224 candidate structured RNAs by comparative analysis of specific subsets of intergenic regions". Nucleic Acids Res. 45 (18): 10811–10823. doi:10.1093/nar/gkx699. PMC 5737381. PMID 28977401.