NCK-interacting protein with SH3 domain is a protein that in humans is encoded by the NCKIPSD gene.[4][5][6]

NCKIPSD
Identifiers
AliasesNCKIPSD, AF3P21, DIP, DIP1, ORF1, SPIN90, VIP54, WASLBP, WISH, NCK interacting protein with SH3 domain
External IDsOMIM: 606671; MGI: 1931834; HomoloGene: 9514; GeneCards: NCKIPSD; OMA:NCKIPSD - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_184231
NM_016453

NM_030729

RefSeq (protein)

NP_057537
NP_909119

NP_109654

Location (UCSC)Chr 3: 48.67 – 48.69 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is localized exclusively in the cell nucleus. It plays a role in signal transduction, and may function in the maintenance of sarcomeres and in the assembly of myofibrils into sarcomeres. It also plays an important role in stress fiber formation. The gene is involved in therapy-related leukemia by a chromosomal translocation t(3;11)(p21;q23) that involves this gene and the myeloid/lymphoid leukemia gene. Alternative splicing occurs in this locus and two transcript variants encoding distinct isoforms have been identified.[6]

Interactions

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NCKIPSD has been shown to interact with Grb2[7][8] and NCK1.[9]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000213672Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ Sano K, Hayakawa A, Piao JH, Kosaka Y, Nakamura H (February 2000). "Novel SH3 protein encoded by the AF3p21 gene is fused to the mixed lineage leukemia protein in a therapy-related leukemia with t(3;11) (p21;q23)". Blood. 95 (3): 1066–8. doi:10.1182/blood.V95.3.1066.003k11_1066_1068. PMID 10648423.
  5. ^ de Bernard M, Moschioni M, Napolitani G, Rappuoli R, Montecucco C (January 2000). "The VacA toxin of Helicobacter pylori identifies a new intermediate filament-interacting protein". The EMBO Journal. 19 (1): 48–56. doi:10.1093/emboj/19.1.48. PMC 1171776. PMID 10619843.
  6. ^ a b "Entrez Gene: NCKIPSD NCK interacting protein with SH3 domain".
  7. ^ Satoh S, Tominaga T (October 2001). "mDia-interacting protein acts downstream of Rho-mDia and modifies Src activation and stress fiber formation". The Journal of Biological Chemistry. 276 (42): 39290–4. doi:10.1074/jbc.M107026200. PMID 11509578.
  8. ^ Fukuoka M, Suetsugu S, Miki H, Fukami K, Endo T, Takenawa T (February 2001). "A novel neural Wiskott-Aldrich syndrome protein (N-WASP) binding protein, WISH, induces Arp2/3 complex activation independent of Cdc42". The Journal of Cell Biology. 152 (3): 471–82. doi:10.1083/jcb.152.3.471. PMC 2196001. PMID 11157975.
  9. ^ Lim CS, Park ES, Kim DJ, Song YH, Eom SH, Chun JS, Kim JH, Kim JK, Park D, Song WK (April 2001). "SPIN90 (SH3 protein interacting with Nck, 90 kDa), an adaptor protein that is developmentally regulated during cardiac myocyte differentiation". The Journal of Biological Chemistry. 276 (16): 12871–8. doi:10.1074/jbc.M009411200. PMID 11278500.

Further reading

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