Murdaugh is a surname. Notable people with this surname include:
- Angela Murdaugh (born 1940), American nurse
- Murdaugh family
- Randolph Murdaugh Sr. (1887–1940), American attorney
- Randolph Murdaugh Jr. (1915–1998), American attorney
- Randolph Murdaugh III (1939–2021), American attorney
- Alex Murdaugh (born 1968)