MtlS RNA is a small non-coding RNA found in Vibrio cholerae and related bacteria.[1] MtlS is found in the mannitol operon, which encodes the mannitol-specific phosphotransferase system. The MtlS RNA is expressed when the bacteria are grown on carbon sources other than mannitol. MtlS is responsible for the post-transcriptional regulation of the MtlA protein. Overexpression of MtlS represses MtlA synthesis; it is proposed that this repression occurs as MtlS base pairs with the mtlA mRNA and occludes the ribosome binding site, thus inhibiting synthesis of the mannitol-specific phosphotransferase system.[2]
References edit
- ^ Liu, Jane M.; Livny, Jonathan; Lawrence, Michael S.; Kimball, Marc D.; Waldor, Matthew K.; Camilli, Andrew (April 2009). "Experimental discovery of sRNAs in Vibrio cholerae by direct cloning, 5S/tRNA depletion and parallel sequencing". Nucleic Acids Research. 37 (6): e46. doi:10.1093/nar/gkp080. PMC 2665243. PMID 19223322.
- ^ Mustachio, L. M.; Aksit, S.; Mistry, R. H.; Scheffler, R.; Yamada, A.; Liu, J. M. (2011). "The Vibrio cholerae Mannitol Transporter is Regulated Posttranscriptionally by the MtlS Small Regulatory RNA". Journal of Bacteriology. 194 (3): 598–606. doi:10.1128/JB.06153-11. PMC 3264093. PMID 22101846.
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