Montelupo can refer to:
- Domagnano, castello in San Marino, formerly known as Domagnano after its coat of arms
- Montelupo Albese, Province of Cuneo, Piedmont, Italy
- Montelupo Fiorentino, Province of Florence, Tuscany, Italy
- Raffaello da Montelupo - Italian sculptor
- Baccio da Montelupo - Italian painter