Mobile and Ohio Railroad Depot may refer to:
- Mobile and Ohio Railroad Depot (Murphysboro, Illinois), listed on the National Register of Historic Places in Jackson County, Illinois
- Mobile and Ohio Railroad Depot (Aberdeen, Mississippi), listed on the National Register of Historic Places in Monroe County, Mississippi
This disambiguation page lists articles associated with the title Mobile and Ohio Railroad Depot.
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If an internal link led you here, you may wish to change the link to point directly to the intended article.