Milhous(e) may refer to:
- Katherine Milhous (1894–1977), newspaper illustrator
- David Milhous (born 1967), film editor
- Richard Milhous Nixon (1913–1994), thirty-seventh president of the United States
- Hannah Milhous Nixon (1885–1967), mother of President Richard Milhous Nixon
- Milhouse Van Houten, character from The Simpsons