Born and raised in Luxembourg, after finishing his medical studies at the University of Basel, 1986 he started working at the Medical Research Council Laboratory of Molecular Biology affiliated with the University of Cambridge.
Goedert was awarded the Potamkin Prize in 1998 and the European Grand Prix for Research by the Foundation for Research on Alzheimer's disease in 2014. In 2018 he was one of four recipients of the Grete Lundbeck European Brain Research Prize with the citation "For their groundbreaking research on the genetic and molecular basis of Alzheimer’s disease, with far-reaching implications for the development of new therapeutic interventions as well as for the understanding of other neurodegenerative diseases of the brain". In 2019 he received the Royal Medal.
Goedert's work combines biochemical, molecular biological and structural techniques to investigate common neurodegenerative diseases, including Alzheimer’s and Parkinson’s. His research focused on the abnormal filamentous inclusions that characterise Parkinson’s and Alzheimer’s, showing that the intracellular filaments of these diseases are made of either alpha-synuclein or tau protein. Goedert's team identified mutations in MAPT, the tau gene, that cause rare inherited forms of frontotemporal dementia with tau inclusions, establishing a central role for tau assembly in the disease.
- Irene Litvan, ed. (2005). "Neurodegenerative α-Synucleinopathies". Atypical Parkinsonian disorders: clinical and research aspects. Springer. ISBN 978-1-58829-331-2.
- "Michel Goedert". Alzforum. 19 October 2008. Retrieved 4 September 2012.
- "The Brain Prize Winners 2018 - Lundbeckfonden - The Brain Prize". www.thebrainprize.org. Retrieved 2018-05-02.
- Royal Medal 2019
- "Biography Michel Goedert - Lundbeckfonden - The Brain Prize". www.thebrainprize.org. Retrieved 2018-12-06.
- Biology, ©2018 MRC Laboratory of Molecular; Avenue, Francis Crick; Campus, Cambridge Biomedical; CB2 0QH, Cambridge; Uk. 01223 267000. "Michel Goedert". MRC Laboratory of Molecular Biology. Retrieved 2018-12-06.