Michael Grunstein

Michael Grunstein (born 1946, in Romania) is a Distinguished Professor Emeritus of Biological Chemistry at the David Geffen School of Medicine at UCLA.[1][2]

Michael Grunstein
Mgrunstein.jpg
Born1946 (age 73–74)
Alma materMcGill University
University of Edinburgh
Awardsthe Massry Prize from the Keck School of Medicine, University of Southern California in 2003, Albert Lasker Award for Basic Medical Research in 2018
Scientific career
FieldsBiological Chemistry
InstitutionsDavid Geffen School of Medicine at UCLA

The only surviving child of Holocaust survivors,[3] he obtained his Bachelor of Science degree from McGill University in Montreal, and his PhD from the University of Edinburgh, Scotland. He did his post-doctoral training at Stanford University in Palo Alto, California, where he invented the colony hybridization screening technique for recombinant DNAs in David Hogness' laboratory.[4]

After coming to UCLA in 1975, Grunstein pioneered the genetic analysis of histones in yeast and showed for the first time that histones are regulators of gene activity in living cells.[5] His laboratory's studies provided inspiration for the eukaryotic histone code and underlie the modern study of epigenetics.[2] His work, which "catapulted the field forward", was recognized in 2018 with the Albert Lasker Award for Basic Medical Research.[6]

Honors and awardsEdit

See alsoEdit

ReferencesEdit

  1. ^ Morber, J. R. (2011). "Profile of Michael Grunstein". Proceedings of the National Academy of Sciences. 108 (46): 18597–18599. Bibcode:2011PNAS..10818597M. doi:10.1073/pnas.1116909108. PMC 3219104. PMID 22084101.
  2. ^ a b "Michael Grunstein, Ph.D. Distinguished Professor, Biological Chemistry, David Geffen School of Medicine, UCLA". Retrieved 2011-11-17.
  3. ^ Morber, Jenny Ruth (2011). "Profile of Michael Grunstein". Proceedings of the National Academy of Sciences. 108 (46): 18597–18599. Bibcode:2011PNAS..10818597M. doi:10.1073/pnas.1116909108. PMC 3219104. PMID 22084101.
  4. ^ Grunstein, M.; Hogness, D. S. (1975). "Colony hybridization: A method for the isolation of cloned DNAs that contain a specific gene". Proceedings of the National Academy of Sciences of the United States of America. 72 (10): 3961–3965. Bibcode:1975PNAS...72.3961G. doi:10.1073/pnas.72.10.3961. PMC 433117. PMID 1105573.
  5. ^ Han, M.; Grunstein, M. (23 December 1988). "Nucleosome Loss Activates Yeast Downstream Promoters in Vivo". Cell. 55 (6): 1137–1145. doi:10.1016/0092-8674(88)90258-9.
  6. ^ a b Grunstein, Michael. "2018 Lasker Awards for Basic Medical Research". Retrieved 24 November 2018.
  7. ^ "2016 Gruber Genetics Prize | Gruber Foundation". gruber.yale.edu.

External linksEdit