Methaphenilene

Methaphenilene
Identifiers
	IUPAC name N,N-Dimethyl-N′-phenyl-N′-(thiophen-2-ylmethyl)ethane-1,2-diamine;
CAS Number	493-78-7 ;
ChemSpider	9884 ;
UNII	Q1MP2MRW1E;
CompTox Dashboard (EPA)	DTXSID5020817 ;
ECHA InfoCard	100.007.074
Chemical and physical data
Formula	C15H20N2S
Molar mass	260.40 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CN(C)CCN(Cc1cccs1)c2ccccc2;
	InChI InChI=InChI=1S/C15H20N2S/c1-16(2)10-11-17(13-15-9-6-12-18-15)14-7-4-3-5-8-14/h3-9,12H,10-11,13H2,1-2H3 ; Key:LDYJXVUOVPVZKA-UHFFFAOYSA-N ;

Methaphenilene is an antihistamine and anticholinergic.

Synthesis edit

Methaphenilene can be synthesized from N,N-dimethyl-N′-phenylethane-1,2-diamine by alkylation with 2-(chloromethyl)thiophene.^[1]

Methaphenilene synthesis

^ Leonard F, Solmssen UV (June 1948). "Thenyl Substituted Diamines with Antihistaminic Activity". Journal of the American Chemical Society. 70 (6): 2064–7. doi:10.1021/ja01186a023. PMID 18863797.

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Identifiers

IUPAC name N,N-Dimethyl-N′-phenyl-N′-(thiophen-2-ylmethyl)ethane-1,2-diamine
CAS Number	493-78-7^Y
ChemSpider	9884^Y
UNII	Q1MP2MRW1E
CompTox Dashboard (EPA)	DTXSID5020817
ECHA InfoCard	100.007.074
Chemical and physical data
Formula	C₁₅H₂₀N₂S
Molar mass	260.40 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CN(C)CCN(Cc1cccs1)c2ccccc2
InChI InChI=InChI=1S/C15H20N2S/c1-16(2)10-11-17(13-15-9-6-12-18-15)14-7-4-3-5-8-14/h3-9,12H,10-11,13H2,1-2H3^Y Key:LDYJXVUOVPVZKA-UHFFFAOYSA-N^Y