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Mestranol/norethynodrel was the first combined oral contraceptive pill (COCP) being mestranol and norethynodrel. It sold as Enovid in the United States and as Enavid in the United Kingdom. Developed by Dr. Gregory Pincus at G. D. Searle & Company, it was first approved on June 10, 1957 by the U.S. Food and Drug Administration for treatment of menstrual disorders.[1] The FDA approved an additional indication for use as a contraceptive on June 23, 1960, though it only became legally prescribable nationwide and regardless of the woman's martial status after Eisenstadt v. Baird in 1972.[2][3][4][5] In 1961, it was approved as a contraceptive in the UK and in Canada.[6][7]

Enovid first came in a bottle.
Combination of
Mestranol Estrogen
Norethynodrel Progestogen
Clinical data
Trade names Enavid, Enovid
Routes of
By mouth
ATC code
Legal status
Legal status
  • Discontinued
PubChem CID

Enovid was discontinued in the U.S. in 1988, along with other first-generation high-estrogen COCPs.[8][9]

See alsoEdit


  1. ^ White Junod, Ph.D., Suzanne (1998). "FDA's Approval of the First Oral Contraceptive, Enovid". Histories of Product Regulation. Update (bimonthly publication of the Food and Drug Law Institute). U.S. Food and Drug Administration. 
  2. ^ "FDA Approved Drug Products". FDA. 
  3. ^ Junod, S. W.; Marks, L (2002). "Women's trials: the approval of the first oral contraceptive pill in the United States and Great Britain" (PDF). Journal of the History of Medicine and Allied Sciences. 57 (2): 117–60. doi:10.1093/jhmas/57.2.117. PMID 11995593. 
  4. ^ Tone, Andrea (2001). Devices & Desires: A History of Contraceptives in America. New York: Hill and Wang. ISBN 0-8090-3817-X. 
  5. ^ Watkins, Elizabeth Siegel (1998). On the Pill: A Social History of Oral Contraceptives, 1950–1970. Baltimore: Johns Hopkins University Press. ISBN 0-8018-5876-3. 
  6. ^ "ANNOTATIONS". Br Med J. 2 (5258): 1007–9. October 14, 1961. doi:10.1136/bmj.2.3490.1009. PMC 1970146 . PMID 20789252. 
  7. ^ "Medical News". Br Med J. 2 (5258): 1032–1034. October 14, 1961. doi:10.1136/bmj.2.5258.1032. PMC 1970195 . 
  8. ^ Reuters News Service (1988-04-15). "Searle, 2 others to stop making high-estrogen pill". St. Louis Post-Dispatch. pp. 7D. Retrieved 2009-08-29. 
  9. ^ "High-estrogen 'pill' going off market". San Jose Mercury News. 1988-04-15. Retrieved 2009-08-29. 

External linksEdit

  • Snider, Sharon. "The Pill: 30 Years of Safety Concerns". FDA Consumer. Rockville, MD: U.S. Food and Drug Administration (December 1990): 9–11. OCLC 25936326.