Mestranol/norethynodrel was the first combined oral contraceptive pill (COCP) being mestranol and norethynodrel. It sold as Enovid in the United States and as Enavid in the United Kingdom. Developed by Dr. Gregory Pincus at G. D. Searle & Company, it was first approved on June 10, 1957 by the U.S. Food and Drug Administration for treatment of menstrual disorders. The FDA approved an additional indication for use as a contraceptive on June 23, 1960. In 1961, it was approved as a contraceptive in the UK and in Canada.
Enovid first came in a bottle.
|Trade names||Enavid, Enovid|
- White Junod, Ph.D., Suzanne (1998). "FDA's Approval of the First Oral Contraceptive, Enovid". Histories of Product Regulation. Update (bimonthly publication of the Food and Drug Law Institute). U.S. Food and Drug Administration.
- "FDA Approved Drug Products". FDA.
- Junod, S. W.; Marks, L (2002). "Women's trials: the approval of the first oral contraceptive pill in the United States and Great Britain" (PDF). Journal of the History of Medicine and Allied Sciences. 57 (2): 117–60. doi:10.1093/jhmas/57.2.117. PMID 11995593.
- "ANNOTATIONS". Br Med J. 2 (5258): 1007–9. October 14, 1961. doi:10.1136/bmj.2.3490.1009. PMC . PMID 20789252.
- "Medical News". Br Med J. 2 (5258): 1032–1034. October 14, 1961. doi:10.1136/bmj.2.5258.1032. PMC .
- Reuters News Service (1988-04-15). "Searle, 2 others to stop making high-estrogen pill". St. Louis Post-Dispatch. pp. 7D. Retrieved 2009-08-29.
- "High-estrogen 'pill' going off market". San Jose Mercury News. 1988-04-15. Retrieved 2009-08-29.