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Mesoamerica(n) or Meso-America(n) (lit. "mid/middle America") may refer to:
- Mesoamerica, an archaeological culture area in the Americas within which a number of pre-Columbian societies flourished before colonization by the Spanish
- Mesoamerican Linguistic Area, a defined linguistic area or sprachbund comprising numerous indigenous languages in Mesoamerica that exhibit certain similarities
- Mesoamerican Barrier Reef System, system of coral reefs in the Caribbean Sea along the coast of Yucatán and Central America
- Mesoamerican Biological Corridor, a biodiversity conservation initiative formed in 1997 to interconnect a number of protected areas in Mesoamerica
- Mesoamerican region, a trans-national economic territory comprising Central America and the southeastern states of Mexico
- Universidad Mesoamericana, a university in Guatemala with campuses in Guatemala City and Quetzaltenango
- Americas (terminology)
- Central America
- Middle America, a wider region in the mid-latitudes of the Americas
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