Mersereau is a surname. Notable people with the surname include:
- Bob Mersereau, Canadian arts journalist
- Jacques Mersereau, set decorator
- Marcelle Mersereau (born 1942), Canadian politician
- Paul Mersereau (1873–?), French painter
- Scott Mersereau (born 1965), American football player
- Violet Mersereau (1892–1975), American stage and film actress
- John LaGrange Mersereau (1731–1820), American spy and soldier
- Joshua Mersereau (1728–1804), Major in the United States army