Mendiburu is a Basque surname. Notable people with this surname include:
- Javier Mendiburu (born 1980), Spanish basketball player
- Luis Ángel Mendiburu, Triple A murder victim
- Manuel de Mendiburu (1805–1885), Peruvian statesman
- Sandrine Mendiburu (born 1972), French golfer
- Michael MendiburuCuyama Basque Handball Player (born 1996)