Melange comes from the French meaning of a "mixture" or "medley". It may also refer to:
- Melange (fictional drug), in Frank Herbert's Dune series novels
- Mélange (rocket fuel component)
- Mélange, a type of rock with block-in-matrix structure containing diverse blocks of rocks
- Melange (yarn), yarns made with mixed fibers dyed before yarn spinning
- Wiener Melange ("Viennese blend"), a specialty coffee, similar to a cappuccino