Mater Dei High School may refer to:
- Mater Dei High School (Santa Ana, California), Catholic high school in Orange County, California
- Mater Dei High School (Breese, Illinois), Catholic high school in Clinton County, Illinois
- Mater Dei High School (Evansville, Indiana), Catholic high school in Vanderburgh County, Indiana
- Mater Dei High School (New Jersey), Catholic high school in Middletown Township, New Jersey
- Mater Dei Catholic High School (Chula Vista, California)
- Mater Dei Catholic College, Catholic high school in Wagga Wagga, New South Wales, Australia
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