Mary Griffith may refer to:
- Mary Agnes Christina Mesmer Griffith (1864–1948), called Tina, American oldest daughter of Louis and Catherine Mesmer
- Mary Griffith (writer) (1772–1846), American writer, horticulturist, and scientist
- Mary Griffith (activist) (1934–2020), American LGBT rights activist
- Mary Harriett Griffith (1849–1930), Australian philanthropist
- Mary Lavinia Griffith (1906–1993), American rancher and conservationist
This disambiguation page lists articles about people with the same name.
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