Mark Douglas may refer to:
- Mark Douglas (politician) (1829–1900), American farmer, businessman, and politician in Wisconsin
- Mark Douglas (ethicist) (born 1966), professor of Christian ethics at Columbia Theological Seminary
- Mark Douglas (cricketer) (born 1968), New Zealand cricketer
- Mark Douglas (rugby union) (born 1960), Welsh rugby union player
- Mark Douglas, co-creator of YouTube channel The Key of Awesome
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