Marcus Raichle

Marcus E. Raichle (born March 15, 1937) is an American neurologist at the Washington University School of Medicine in Saint Louis, Missouri. He is a professor in the Department of Radiology with joint appointments in Neurology, Neurobiology and Biomedical Engineering. His research over the past 40 years has focused on the nature of functional brain imaging signals arising from PET and fMRI and the application of these techniques to the study of the human brain in health and disease.[1] He received the Kavli Prize in Neuroscience “for the discovery of specialized brain networks for memory and cognition", together with Brenda Milner and John O’Keefe in 2014.

Marcus Raichle
Marcus Raichle 2014.jpg
Marcus Raichle in 2014
Born (1937-03-15) March 15, 1937 (age 83)
Known fordefault mode, functional neuroimaging
AwardsGrawemeyer Award in Psychology (2001)
Kavli Prize in Neuroscience (2014)
Scientific career
InstitutionsWashington University in St. Louis


Noteworthy accomplishments of Marcus Raichle include the discovery of the relative independence of blood flow and oxygen consumption during changes in brain activity which provided the physiological basis of fMRI;[2] the discovery of a default mode of brain function (i.e., organized intrinsic activity) and its signature system,[3] the brain’s default mode network;[4] and, the discovery that aerobic glycolysis contributes to brain function independent of oxidative phosphorylation.[5][6]



In 2001, he was a co-recipient of Grawemeyer Award in Psychology, with Michael Posner and Steven Petersen of the University of Louisville.[8] In 2010, he was awarded the Ariëns Kappers Medal from the Royal Netherlands Academy of Arts and Sciences. In 2014, he was a co-recipient of the Kavli Prize in Neuroscience, awarded by the Norwegian Academy of Science and Letters, with Brenda Milner of the Montreal Neurological Institute at McGill University and John O’Keefe of University College London.[9]

Selected publicationsEdit


  1. ^ "Academy Members". Archived from the original on October 8, 2011.
  2. ^ Petersen, SE; Fox PT; Posner MI; Mintun M; Raichle ME (1988). "Positron emission tomographic studies of the cortical anatomy of single-word processing". Nature. 331 (6157): 585–589. doi:10.1038/331585a0. PMID 3277066.
  3. ^ Raichle, M. E.; MacLeod, A. M.; Snyder, A. Z.; Powers, W. J.; Gusnard, D. A.; Shulman, G. L. (January 16, 2001). "A default mode of brain function". Proceedings of the National Academy of Sciences of the United States of America. 98 (2): 676–682. doi:10.1073/pnas.98.2.676. ISSN 0027-8424. PMC 14647. PMID 11209064.
  4. ^ Fox, MD; Zhang D; Snyder DZ; Raichle ME (2009). "The global signal and observed anticorrelated resting state brain networks". J. Neurophysiol. 101 (6): 3270–3283. doi:10.1152/jn.90777.2008. PMC 2694109. PMID 19339462.
  5. ^ Vaishnavi, SN; Vlassenko AG; Rundle MM; Snyder AZ; Mintun MA; Raichle ME (2010). "Regional aerobic glycolysis in the human brain". PNAS. 107 (41): 17757–17762. doi:10.1073/pnas.1010459107. PMC 2955101. PMID 20837536.
  6. ^ Vlassenko AG, Vaishnavi SN, Couture L, Sacco D, Shannon BJ, Mac, RH, Morris JC, Raichle ME, Mintun MA (2010). "Spatial correlation between brain aerobic glycolysis and amyloid-β deposition". PNAS. 107 (41): 17763–17767. doi:10.1073/pnas.1010461107. PMC 2955133. PMID 20837517.
  7. ^ "Utenlandske medlemmer | Det Norske Videnskaps-Akademi". Retrieved January 28, 2020.
  8. ^ "2001– Michael Posner, Marcus Raichle and Steven Petersen". Archived from the original on May 21, 2014.
  9. ^ Bhattacharjee, Yudhijit (May 29, 2014). "Nine Scientists Share Three Kavli Prizes".

External linksEdit