Manuel Villegas may refer to:
- Manuel Delgado Villegas (1943–1998), Spanish serial killer
- Manuel Villegas (golfer) (born 1984), Colombian golfer
- Manuel Villegas (swimmer) (1908–?), Mexican swimmer
- Manuel Villegas Piñateli (died 1752), member of the Royal Spanish Academy
This disambiguation page lists articles about people with the same name.
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