Manuel Vargas may refer to:
- Manuel Vargas (footballer) (born 1991), Panamanian footballer
- Manuel Vargas (boxer) (born 1981), professional boxer
- Manuel Vargas (singer), lead member of the Mariachi Sangre Mexicana
- Manuel Cepeda Vargas (1930–1994), lawyer and Senator of Colombia
- Manuel Francisco de Vargas (1849-1921), Portuguese engineer and politician
This disambiguation page lists articles about people with the same name.
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