Mac Nisse, an early Irish matronymic meaning "son of Ness", may refer to:
- Mac Nisse of Connor, founding saint of Connor, Co. Antrim (d. 514)
- Mac Nisse, third abbot of Clonmacnoise (d. 580s)
- Fergus Mór, a legendary king of the Díal Riata (5th century)
- Domangart Réti, Fergus's son and successor (early 6th century)
This disambiguation page lists articles about people with the same name.
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