Myosin regulatory light chain interacting protein, also known as MYLIP, is a protein that in humans is encoded by the MYLIP gene.[5]

MYLIP
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMYLIP, IDOL, MIR, myosin regulatory light chain interacting protein
External IDsOMIM: 610082; MGI: 2388271; HomoloGene: 8309; GeneCards: MYLIP; OMA:MYLIP - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_013262

NM_153789

RefSeq (protein)

NP_037394

NP_722484

Location (UCSC)Chr 6: 16.13 – 16.15 MbChr 13: 45.54 – 45.57 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

MYLIP is also known as IDOL "Inducible Degrader of the LDL receptor" based on its involvement in cholesterol regulation or MIR "Modulator Of Immune Recognition".[6][7] The expression of IDOL is induced by the sterol-activated liver X receptor.

Increased Degradation of LDL Receptor Protein (IDOL) is a ubiquitin ligase that ubiquinates LDL receptors in endosomes and directs the receptors to the lysosomal compartment for degradation. IDOL is transcriptionally up-regulated by LXR/RXR in response to an increase in intracellular cholesterol.[8] Pharmacologic inhibition of IDOL could reduce plasma LDL cholesterol by increasing plasma LDL receptor density.

Function

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The ERM protein family members ezrin, radixin, and moesin are cytoskeletal effector proteins linking actin to membrane-bound proteins at the cell surface. Myosin regulatory light chain interacting protein (MYLIP) is a novel ERM-like protein that interacts with myosin regulatory light chain and inhibits neurite outgrowth.[5]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000007944Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038175Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: MYLIP myosin regulatory light chain interacting protein".
  6. ^ Zelcer N, Hong C, Boyadjian R, Tontonoz P (July 2009). "LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor". Science. 325 (5936): 100–4. Bibcode:2009Sci...325..100Z. doi:10.1126/science.1168974. PMC 2777523. PMID 19520913.
  7. ^ Lindholm D, Bornhauser BC, Korhonen L (November 2009). "Mylip makes an Idol turn into regulation of LDL receptor". Cell. Mol. Life Sci. 66 (21): 3399–402. doi:10.1007/s00018-009-0127-y. PMC 11115883. PMID 19688294. S2CID 34153384.
  8. ^ Sawamura, T. (2009). "New Idol for cholesterol reduction?". Clin. Chem. 55 (12): 2082–2084. doi:10.1373/clinchem.2009.134023. PMID 19833835.

Further reading

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