MRPS35

28S ribosomal protein S35, mitochondrial is a protein that in humans is encoded by the MRPS35 gene.

MRPS35
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3J9M
Identifiers
Aliases	MRPS35, MDS023, MRP-S28, MRPS28, HDCMD11P, mitochondrial ribosomal protein S35
External IDs	OMIM: 611995; MGI: 2385255; HomoloGene: 11048; GeneCards: MRPS35; OMA:MRPS35 - orthologs
Gene location (Human) Chr. Chromosome 12 (human) Band 12p11.22 Start 27,710,822 bp End 27,756,295 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6|6 G3 Start 146,944,262 bp End 146,975,489 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in rectum mucosa of transverse colon Achilles tendon tibialis anterior muscle gastrocnemius muscle mucosa of ileum deltoid muscle Skeletal muscle tissue of rectus abdominis right adrenal gland right adrenal cortex Top expressed in interventricular septum right kidney embryo embryo right ventricle myocardium of ventricle ventricular zone proximal tubule epiblast muscle of thigh More reference expression data BioGPS More reference expression data
Gene ontology Molecular function structural constituent of ribosome RNA binding Cellular component mitochondrial inner membrane ribosome mitochondrial small ribosomal subunit mitochondrion Biological process mitochondrial translational elongation mitochondrial translational termination mitochondrial translation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 60488 232536 Ensembl ENSG00000061794 ENSMUSG00000040112 UniProt P82673 Q8BJZ4 RefSeq (mRNA) NM_021821 NM_001190864 NM_145573 RefSeq (protein) NP_001177793 NP_068593 NP_663548 Location (UCSC) Chr 12: 27.71 – 27.76 Mb Chr 6: 146.94 – 146.98 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that has had confusing nomenclature in the literature. Pseudogenes corresponding to this gene are found on chromosomes 3p, 5q, and 10q.

Further reading

• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ishiguchi H, Izumi H, Torigoe T, et al. (2004). "ZNF143 activates gene expression in response to DNA damage and binds to cisplatin-modified DNA". Int. J. Cancer. 111 (6): 900–9. doi:10.1002/ijc.20358. PMID 15300802. S2CID 37308382.
• Zhang Z, Gerstein M (2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome". Genomics. 81 (5): 468–80. doi:10.1016/S0888-7543(03)00004-1. PMID 12706105.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Kenmochi N, Suzuki T, Uechi T, et al. (2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders". Genomics. 77 (1–2): 65–70. doi:10.1006/geno.2001.6622. PMID 11543634.
• Koc EC, Burkhart W, Blackburn K, et al. (2001). "Identification of four proteins from the small subunit of the mammalian mitochondrial ribosome using a proteomics approach". Protein Sci. 10 (3): 471–81. doi:10.1110/ps.35301. PMC 2374141. PMID 11344316.

External links

• Overview of all the structural information available in the PDB for UniProt: P82673 (28S ribosomal protein S35, mitochondrial) at the PDBe-KB.