Stromelysin-2 also known as matrix metalloproteinase-10 (MMP-10) or transin-2 is an enzyme that in humans is encoded by the MMP10 gene.[5][6]

MMP10
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMMP10, SL-2, STMY2, matrix metallopeptidase 10
External IDsOMIM: 185260; MGI: 97007; HomoloGene: 20546; GeneCards: MMP10; OMA:MMP10 - orthologs
EC number3.4.24.22
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002425

NM_019471

RefSeq (protein)

NP_002416

NP_062344

Location (UCSC)Chr 11: 102.77 – 102.78 MbChr 9: 7.5 – 7.51 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans and fibronectin. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.[7]

Clinical significance

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MMP10 has been linked to cancer stem cell vitality and metastasis.[8]

MMP10 is a potential prognostic biomarker for oral cancer.[9][unreliable medical source]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000166670Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000047562Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Muller D, Quantin B, Gesnel MC, Millon-Collard R, Abecassis J, Breathnach R (July 1988). "The collagenase gene family in humans consists of at least four members". The Biochemical Journal. 253 (1): 187–92. doi:10.1042/bj2530187. PMC 1149273. PMID 2844164.
  6. ^ Jung JY, Warter S, Rumpler Y (1990). "Localization of stromelysin 2 gene to the q22.3-23 region of chromosome 11 by in situ hybridization". Annales de Génétique. 33 (1): 21–3. PMID 2369069.
  7. ^ "Entrez Gene: MMP10 matrix metallopeptidase 10 (stromelysin 2)".
  8. ^ Justilien V, Regala RP, Tseng IC, Walsh MP, Batra J, Radisky ES, Murray NR, Fields AP (2012). "Matrix metalloproteinase-10 is required for lung cancer stem cell maintenance, tumor initiation and metastatic potential". PLOS ONE. 7 (4): e35040. Bibcode:2012PLoSO...735040J. doi:10.1371/journal.pone.0035040. PMC 3335833. PMID 22545096.
  9. ^ Upadhyay P, Gardi N, Desai S, Chandrani P, Joshi A, Dharavath B, Arora P, Bal M, Nair S, Dutt A (2017). "Genomic characterization of tobacco/nut chewing HPV-negative early stage tongue tumors identify MMP10 asa candidate to predict metastases". Oral Oncology. 73: 56–64. doi:10.1016/j.oraloncology.2017.08.003. PMC 5628952. PMID 28939077.

Further reading

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  • The MEROPS online database for peptidases and their inhibitors: M10.006
  • Overview of all the structural information available in the PDB for UniProt: P09238 (Stromelysin-2) at the PDBe-KB.