Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A is an enzyme that in humans is encoded by the MGAT5 gene.[5][6]

MGAT5
Identifiers
AliasesMGAT5, GNT-V, GNT-VA, mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase, MGAT5A, glcNAc-T V
External IDsOMIM: 601774; MGI: 894701; HomoloGene: 1808; GeneCards: MGAT5; OMA:MGAT5 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002410
NM_001371457

NM_145128

RefSeq (protein)

NP_002401
NP_001358386

NP_660110

Location (UCSC)Chr 2: 134.12 – 134.45 MbChr 1: 127.13 – 127.42 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, a glycosyltransferase involved in the synthesis of protein-bound and lipid-bound oligosaccharides. Alterations of the oligosaccharides on cell surface glycoproteins cause significant changes in the adhesive or migratory behavior of a cell. Increase in the encoded protein's activity may correlate with the progression of invasive malignancies.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000152127Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036155Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Saito H, Nishikawa A, Gu J, Ihara Y, Soejima H, Wada Y, Sekiya C, Niikawa N, Taniguchi N (Feb 1994). "cDNA cloning and chromosomal mapping of human N-acetylglucosaminyltransferase V+". Biochem Biophys Res Commun. 198 (1): 318–27. doi:10.1006/bbrc.1994.1045. PMID 8292036.
  6. ^ a b "Entrez Gene: MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase".

Further reading

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