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M̃–m̃ is or was used as a grapheme in several languages:
- in some languages of Vanuatu, such as North Efate, South Efate and Namakura, it represents a labial-velar nasal [ŋm]. The letter was introduced by missionaries and has been in use for over a hundred years. (Other Vanuatu languages use an M-macron |m̄| instead.)
- in the Yanesha' language of Peru, m̃ represents a palatalized m
- in Lithuanian, m̃ appears as part of diphthongs
- in the transliteration of the Lycian script, it represents a syllabic m.