Wikipedia

Lyn Chitty

Dame Lyn Susan Chitty DBE is a British physician and Professor of Genetics and Fetal Medicine at University College London. She is the deputy director of the National Institute for Health and Care Research Great Ormond Street Hospital Biomedical Research Centre. She is the 2022 president of the International Society for Prenatal Diagnosis.[1] Her research considers non-invasive prenatal diagnostics. She was made a Dame in the 2022 New Year Honours.

Dame
Lyn Susan Chitty
DBE
Alma materUniversity College London
Known forNon-invasive prenatal diagnostics
Scientific career
InstitutionsGreat Ormond Street Hospital

Early life and education

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Chitty earned her medical degree at the University of London.[2]

Research and career

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Chitty's interest is in prenatal genetic diagnostics and ultrasound screening of fatal skeletal abnormalities, enabling parents to find out about the health of their unborn children.[3] She was appointed a Chair the Great Ormond Street Hospital in 2009.[3]

Noninvasive prenatal testing (NIPT) for conditions such as Down syndrome[4] was made available through commercial providers in the United States and China in 2011, and in the United Kingdom by 2014. Chitty led the National Institute for Health and Care Research RAPID (Reliable, Accurate Prenatal, non-Invasive Diagnosis) programme,[5] which looked to investigate all aspects of non-invasive testing and evaluate how it could be incorporated into the National Health Service.[6] She showed that implementing noninvasive prenatal testing to the NHS was cost-neutral, and reduced the number of women who needed an invasive test to confirm a high-risk result.[7][8][9]

Chitty recruited one third of the rare diseases participants to the 100,000 genome project.[10][11][12] She helped members of the public understand genomics and genomic sequencing. At GOSH she worked with young people to understand public health and genomics.[10] She has argued that the lives of cancer patients will be transformed with genomic testing.[13]

In 2020, she was made President of the International Society for Prenatal Diagnosis.[1] She was appointed a Dame Commander of the British Empire in 2022.[14]

Select publications

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  • Andrew J Copp; N Scott Adzick; Lyn S Chitty; Jack M Fletcher; Grayson N Holmbeck; Gary M Shaw (30 April 2015). "Spina bifida". Nature Reviews Disease Primers. 1: 15007. doi:10.1038/NRDP.2015.7. ISSN 2056-676X. PMC 4898641. PMID 27189655. Wikidata Q28396364.
  • Jenny Lord; Dominic J McMullan; Ruth Y Eberhardt; et al. (23 February 2019). "Prenatal exome sequencing analysis in fetal structural anomalies detected by ultrasonography (PAGE): a cohort study". The Lancet. 393 (10173): 747–757. doi:10.1016/S0140-6736(18)31940-8. ISSN 0140-6736. PMC 6386638. PMID 30712880. Wikidata Q64108553.
  • D G Altman; Lyn S Chitty (1 January 1994). "Charts of fetal size: 1. Methodology". British Journal of Obstetrics and Gynaecology. 101 (1): 29–34. doi:10.1111/J.1471-0528.1994.TB13006.X. ISSN 0306-5456. PMID 8297864. Wikidata Q47380972.

References

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  1. ^ a b "Presidents". ispdhome.org. Retrieved 31 December 2022.
  2. ^ "Lyn Susan Chitty profile". gmc-uk.org. Retrieved 31 December 2022.
  3. ^ a b "Professor Lyn Chitty". norththamesglh.nhs.uk. Retrieved 31 December 2022.
  4. ^ "Down's syndrome has become the newest front in the abortion wars". New Scientist. Retrieved 31 December 2022.
  5. ^ "Lyn Chitty profile". AGBT.org. Retrieved 31 December 2022.
  6. ^ Hill, Melissa; Wright, David; Daley, Rebecca; Lewis, Celine; McKay, Fiona; Mason, Sarah; Lench, Nicholas; Howarth, Abigail; Boustred, Christopher; Lo, Kitty; Plagnol, Vincent; Spencer, Kevin; Fisher, Jane; Kroese, Mark; Morris, Stephen (16 July 2014). "Evaluation of non-invasive prenatal testing (NIPT) for aneuploidy in an NHS setting: a reliable accurate prenatal non-invasive diagnosis (RAPID) protocol". BMC Pregnancy and Childbirth. 14 (1): 229. doi:10.1186/1471-2393-14-229. ISSN 1471-2393. PMC 4226037. PMID 25027965.
  7. ^ "Research leads to safer Down's Syndrome testing for expectant mothers". UCLPartners.com. Retrieved 31 December 2022.
  8. ^ "Down's blood test 'would cut risk of miscarriage'". BBC News. 6 June 2015. Retrieved 31 December 2022.
  9. ^ "First 'in womb' stem cell trial to begin". BBC News. 12 October 2015. Retrieved 31 December 2022.
  10. ^ a b "Professor Lyn Chitty made a Dame in New Year's Honours". gosh.nhs.uk. Retrieved 31 December 2022.
  11. ^ Griffin, Blanche H.; Chitty, Lyn S.; Bitner-Glindzicz, Maria (9 December 2016). "The 100 000 Genomes Project: What it means for paediatrics". Archives of Disease in Childhood: Education and Practice Edition. 102 (2): 105–107. doi:10.1136/archdischild-2016-311029. ISSN 1743-0585. PMID 27940446. S2CID 5231863.
  12. ^ Peter, Michelle; Hammond, Jennifer; Sanderson, Saskia C.; Gurasashvili, Jana; Hunter, Amy; Searle, Beverly; Patch, Christine; Chitty, Lyn S.; Hill, Melissa; Lewis, Celine (May 2022). "Participant experiences of genome sequencing for rare diseases in the 100,000 Genomes Project: a mixed methods study". European Journal of Human Genetics. 30 (5): 604–610. doi:10.1038/s41431-022-01065-2. ISSN 1476-5438. PMC 9091267. PMID 35264738.
  13. ^ "Cancer patients have lives transformed by gene tests". Times.co.uk. ISSN 0140-0460. Retrieved 31 December 2022.
  14. ^ "Lead NHS vaccine nurse and frontline staff among health service honours". england.nhs.uk. Retrieved 31 December 2022.
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