Loss Creek may refer to one of several streams:
Canada edit
- Loss Creek (Canada), in Capital Regional District, British Columbia
United States edit
- Loss Creek, in Spring Creek Township, Coffey County, Kansas
- Loss Creek, in Black Wolf Township, Ellsworth County, Kansas
- Loss Creek, a river in Ohio
- Loss Creek, a tributary of the Hiwassee River in Polk County, Tennessee
- Loss Creek (Texas), in Coleman County, Texas