Lorenzo Onofrio Colonna may refer to:
- Lorenzo Onofrio Colonna, Count of the Marsi (1356–1423), grandfather of Giovanni Colonna (cardinal, 1456–1508)
- Lorenzo Onofrio Colonna, 8th Prince of Paliano (1637–1689)
- Lorenzo Onofrio Colonna, 11th Prince of Paliano (1723–1779), Prince of Paliano
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