In the United States, the single peaked at number four on both the Billboard Hot 100 and the Hot R&B/Hip-Hop Songs. On November 24, 1997, it was certified platinum by the Recording Industry Association of America for sales of one million copies. The song made it to number three in New Zealand and number sixteen in the UK Singles Chart. A music video was released for the single. Bizzy Bone did not appear in it, but the clips from the film were scattered throughout the video. A remix also produced by DJ U-Neek entitled "Look into My Eyes (Atlantis Remix)" was released on the compilation album The Collection: Volume Two.
Chuck Eddy of Entertainment Weekly wrote: "The staccato rap harmonies of these hugely popular Cleveland gangsta youngstas, Bone Thugs-N-Harmony, resulted in startling gospel beauty on earlier hits. "Look Into My Eyes", the first commercial single from the Batman & Robin soundtrack, aims for a hypnotic darkness but ultimately feels tired and trite: spiritless voices dragging themselves through formless tempo shifts over a beatless background blur".[2]AllMusic critic gave the single 1.5 out of five stars.
^Sandiford-Waller, Theda (May 31, 1997). "Hot 100 Singles Spotlight". Billboard. Vol. 109, no. 22. p. 101. Bone Thugs-N-Harmony's 'Look Into My Eyes' (Ruthless/Relativity) and R. Kelly's 'Gotham City' [...] are due at retail June 3 and June 27, respectively.
^"New Releases: Singles". Music Week. July 12, 1997. p. 31.