Little Mo may refer to:
- Maureen Connolly, American tennis player nicknamed "Little Mo"
- Little Mo (film), a made-for-television biopic about Connolly, starring Glynnis O'Connor
- Little Mo Mitchell, a character from the UK television series EastEnders
- Little Missouri River (Arkansas), a river in Arkansas, U.S.
This disambiguation page lists articles associated with the title Little Mo.
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