Academia, business and politics
- Frances Baard
- Manne Dipico
- Unity Dow
- Prof Dan Kgwadi
- Ian Khama
- Khama III
- Sir Seretse Khama
- Keorapetse Kgositsile
- Moses Kotane
- Mpule Kwelagobe
- David Magang
- Supra Mahumapelo
- Mmusi Maimane
- Lucas Mangope
- Sir Ketumile Masire
- Mokgweetsi Masisi
- Joe Matthews
- Z. K. Matthews
- Thandi Modise
- Festus Mogae
- Mogoeng Mogoeng
- Job Mokgoro
- Yvonne Mokgoro
- Popo Molefe
- Edna Molewa
- Kgosi Leruo Molotlegi
- Ruth Mompati
- James Moroka
- Dikgang Moseneke
- Nthato Motlana
- Kgalema Motlanthe
- Patrice Motsepe
- Tshepo Motsepe
- Naledi Pandor
- Dipuo Peters
- Mamokgethi Phakeng
- Sol Plaatje
- Abram Onkgopotse Tiro
Media
- Culture Spears
- Charma Gal
- A-Reece
- Khuli Chana
- Presley Chweneyagae
- Fifi Cooper
- Vuyo Dabula
- DJ Fresh
- Katlego Danke
- Connie Ferguson
- Goapele
- HHP
- Kagiso Lediga
- Gail Nkoane Mabalane
- Kabelo Mabalane
- Motlatsi Mafatshe
- Mothusi Magano
- Bonang Matheba
- Tim Modise
- Bontle Modiselle
- Lerato Molapo
- Tumi Molekane
- Faith Nketsi
- Cassper Nyovest
- Manaka Ranaka
- Rapulana Seiphemo
- Tuks Senganga
- Earl Sweatshirt (American rapper whose father is Tswana)
- Boity Thulo
- Redi Tlhabi
- Emma Wareus
Sports