Line 22 may refer to:
- Line 22 (Guangzhou Metro), a metro line of the Guangzhou Metro in China
- Pinggu Line, a future subway line of the Beijing Subway in China
- Line 22 (São Paulo Metro), a future metro line of the São Paulo Metro in Brazil
- Line 22 (Shanghai Metro), a future metro line of Shanghai Metro in China
This disambiguation page lists articles associated with the title Line 22.
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