Lecithin–cholesterol acyltransferase

Lecithin–cholesterol acyltransferase (LCAT, also called phosphatidylcholine–sterol O-acyltransferase) is an enzyme that converts free cholesterol into cholesteryl ester (a more hydrophobic form of cholesterol), which is then sequestered into the core of a lipoprotein particle, eventually making the newly synthesized HDL spherical and forcing the reaction to become unidirectional since the particles are removed from the surface. The enzyme is bound to high-density lipoproteins (HDLs) (alpha-LCAT) and LDLs (beta-LCAT) in the blood plasma.[5] LCAT deficiency can cause impaired vision due to cholesterol corneal opacities, anemia, and kidney damage.[6] It belongs to the family of phospholipid:diacylglycerol acyltransferases.

LCAT
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesLCAT, entrez:3931, lecithin-cholesterol acyltransferase
External IDsOMIM: 606967 MGI: 96755 HomoloGene: 68042 GeneCards: LCAT
Gene location (Human)
Chromosome 16 (human)
Chr.Chromosome 16 (human)[1]
Chromosome 16 (human)
Genomic location for LCAT
Genomic location for LCAT
Band16q22.1Start67,939,750 bp[1]
End67,944,131 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000229

NM_008490

RefSeq (protein)

NP_000220

NP_032516

Location (UCSC)Chr 16: 67.94 – 67.94 MbChr 8: 105.94 – 105.94 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactive pathway mapEdit

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

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|px|alt=Statin Pathway edit]]
Statin Pathway edit
  1. ^ The interactive pathway map can be edited at WikiPathways: "Statin_Pathway_WP430".

See alsoEdit

ReferencesEdit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000213398 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035237 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Lecithin-Cholesterol Acyltransferase Deficiency: Overview, Presentation, Differential Diagnosis". 2016-08-08. Cite journal requires |journal= (help)
  6. ^ Reference, Genetics Home. "LCAT gene". Genetics Home Reference. Retrieved 2016-12-11.

Further readingEdit

External linksEdit